@article{Lakshmana Rao_Prasanthi_Pothu Raju_Sravanthi_Hema Sai Sri_Prasanthi_Sravan_2018, place={India.}, title={UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ALPRAZOLAM AND MEBEVERINE HYDROCHLORIDE IN BULK DRUG AND PHARMACEUTICAL FORMULATION}, volume={1}, url={https://ijraps.in/index.php/ijraps/article/view/6}, abstractNote={<p>A simple, accurate, precise, sensitive, rapid and economical spectrophotometric method was developed and validated for simultaneous estimation of Alprazolam (ALP) and Mebeverine HCl (MBH) in bulk drug and pharmaceutical formulation. The estimation of these drugs was carried out by using 0.1M HCl as a solvent. The wavelength maxima for Alprazolam and Mebeverine HCl were found to be 262.3 nm and 222.5 nm. The linearity range was observed in the concentration range of 3-15 µg/ml for both drugs and regression equation was found to be for ALP 0.0565x+0.0138 and for MBH 0.049x-0.0126. Percentage recoveries for Alprazolam and Mebeverine HCl were found to be 99.84% and 99.47% respectively. % RSD values for Intra-day precision were found to be for ALP 1.18% and for MBH 0.59%. Inter-day precision %RSD values were found to be for ALP 0.94% and for MBH 0.69%. LOD was found to be for ALP 1.42 (µg/ml) and for MBH 2.1542 (µg/ml). LOQ was found to be for ALP 4.3242 (µg/ml) and for MBH 6.5442 (µg/ml). The %Assay of Alprazolam and Mebeverine HCl were found to be 99.20% and 100.02% respectively. Statistical analysis proved that the developed method can be successfully used for simultaneous analysis of Alprazolam and Mebeverne HCl in pure and tablet dosage forms.</p&gt;}, number={1}, journal={International Journal of Research in AYUSH and Pharmaceutical Sciences}, author={Lakshmana Rao, A. and Prasanthi, T and Pothu Raju, B and Sravanthi, I and Hema Sai Sri, K and Prasanthi, K. and Sravan, V}, year={2018}, month={Jul.}, pages={27-32} }