SYNTHESIS, ANTIMICROBIAL ACTIVITY OF SOME NOVEL SUBSTITUTED THIOPHENE DERIVATIVES

  • B.Satya Sree Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India.
  • A.Lakshmana Rao, M.L.N.T.Amaleswari, M.Udaykiran, M.Sasikala, N.Teja Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India.
Keywords: Cyclohexanone, acetaldehyde, cyanoacetamide malanonitrile.

Abstract

Various novel substituted thiophene derivatives were prepared by Gewald method using cyclohexanone/acetaldehyde treated with elemental sulphur and active nitriles like ethylcyanoacetate, cyanoacetamide and malanonitrile in presence of base morpholine and solvent ethanol to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR& mass) and tested for antimicrobial activity.

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Published
02-07-2020
How to Cite
1.
B.Satya Sree, A.Lakshmana Rao, M.L.N.T.Amaleswari, M.Udaykiran, M.Sasikala, N.Teja. SYNTHESIS, ANTIMICROBIAL ACTIVITY OF SOME NOVEL SUBSTITUTED THIOPHENE DERIVATIVES. IJRAPS [Internet]. 2020Jul.2 [cited 2024Dec.20];3(12):380-4. Available from: https://ijraps.in/index.php/ijraps/article/view/77
Issue
Vol 3, Issue 12: December 2019
Section
Articles