SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF MANNICH BASES CONTAINING MORPHOLINE MOIETY

Abstract

A variety of morpholine derivatives as mannich bases were prepared through mannich reaction by reacting 4-nitro acetophenone as compound containing active hydrogen, substituted benzaldehyde and morpholine as secondary amine compound. All the synthesized compounds structures were characterized by physical analysis data and spectral analysis data (IR and ¹H-NMR spectral analysis). The newly synthesized compounds were evaluated for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa in comparision with standard drug Streptomycin. However the antibacterial activity of the synthesized compounds against the tested organisms was found to possess good to moderate activity.