SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC MANNICH BASES
Keywords: Acetanilide, Substituted benzaldehyde, Morpholine, Methyl amine.
Various novel heterocyclic mannich bases were prepared by using Mannich reaction. Acetanilide was treated with substituted benzaldehyde and morpholine / methyl amine to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR) and tested for antimicrobial activity against Escherichia coli, Bacillus subtilis by using cup plate method with reference to the standard Streptomycin. All the titled compounds show good antimicrobial activity.
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Sree B S, Rao A L, Sindhu A L, P A, B P, A A. SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC MANNICH BASES. IJRAPS [Internet]. 2018Nov.13 [cited 2023May29];2(5):262-4. Available from: https://ijraps.in/index.php/ijraps/article/view/48