SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC MANNICH BASES
Various novel heterocyclic mannich bases were prepared by using Mannich reaction. Acetanilide was treated with substituted benzaldehyde and morpholine / methyl amine to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR) and tested for antimicrobial activity against Escherichia coli, Bacillus subtilis by using cup plate method with reference to the standard Streptomycin. All the titled compounds show good antimicrobial activity.