SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC MANNICH BASES

Satya Sree B; Lakshmana Rao A; Lakshmi Sindhu A; Alekya P; Pavani B; Asha A

Satya Sree B Associate Professor, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
Lakshmana Rao A Professor and Principal, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
Lakshmi Sindhu A Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P.
Alekya P Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
Pavani B Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
Asha A Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P

Keywords: Acetanilide, Substituted benzaldehyde, Morpholine, Methyl amine.

Abstract

Various novel heterocyclic mannich bases were prepared by using Mannich reaction. Acetanilide was treated with substituted benzaldehyde and morpholine / methyl amine to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR) and tested for antimicrobial activity against Escherichia coli, Bacillus subtilis by using cup plate method with reference to the standard Streptomycin. All the titled compounds show good antimicrobial activity.

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