SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC MANNICH BASES

  • Satya Sree B Associate Professor, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
  • Lakshmana Rao A Professor and Principal, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
  • Lakshmi Sindhu A Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P.
  • Alekya P Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
  • Pavani B Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
  • Asha A Student, Department of Pharmaceutical Chemistry, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P
Keywords: Acetanilide, Substituted benzaldehyde, Morpholine, Methyl amine.

Abstract

Various novel heterocyclic mannich bases were prepared by using Mannich reaction. Acetanilide was treated with substituted benzaldehyde and morpholine / methyl amine to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR) and tested for antimicrobial activity against Escherichia coli, Bacillus subtilis by using cup plate method with reference to the standard Streptomycin. All the titled compounds show good antimicrobial activity.

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Published
13-11-2018
How to Cite
1.
Sree B S, Rao A L, Sindhu A L, P A, B P, A A. SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC MANNICH BASES. IJRAPS [Internet]. 2018Nov.13 [cited 2024Apr.27];2(5):262-4. Available from: https://ijraps.in/index.php/ijraps/article/view/48
Issue
Vol 2, Issue 5: May 2018
Section
Articles