A RANDOMISED SINGLE BLIND ACTIVE CONTROLLED, PARALLEL GROUP STUDY COMPARING THE EFFICACY & SAFETY OF THE KARNIM PLUS® CAPSULES IN PATIENTS WITH MILD OR MODERATE DIABETES MELLITUS TYPE. II

  • Chhapekar Shrirang Reader, Dept of Kaychikitsa, Ashwin rural Ayurved College and Hospital, Manchii hill, Dist. Ahmadnagar
  • Deshpande Sarang Head, Clinical Research Department, Unijules Life Sciences Ltd., Nagpur
  • Khandizod Shivapal G Professor, Dept of Kaychikitsa, Ashwin Rural Ayurved College and Hospital, Manchii hill, Dist. Ahmadnagar
  • D. M Padvi Reader, Dr. D.Y. Patil College of Ayurved and Research Hospital, Nerul, Navi Mumbai (MH)
  • Bhadalikar Deodatta Professor, Dr. D.Y. Patil College of Ayurved and Research Hospital, Nerul, Navi Mumbai (MH)
  • Malekar Shailesh Head, Clinical Research Department, Unijules Life Sciences Ltd., Nagpur
Keywords: Karnim plus capsule, Unijules Life Sciences ltd. HbA1c, Herbal treatment.

Abstract

Diabetes is the most prevalent disease in the world affecting middle and old aged persons of the world directly impacting their life style and other metabolic hazards. Karnim plus is a remedy of Unijules Life Sciences ltd. And current multicentric, randomized, single blind, active controlled and parallel group with metformin capsule clinical study is conducted in two centres of Dr. D.Y. Patil College and Ashwin Ayurved college respectively. Total 121 patients were treated according to the previously approved protocol from institutional ethics committee for the treatment period of 24 weeks in a dose of 2 capsules BID before meal and primary efficacy parameters set to HbA1c, fasting and post meal blood sugar. From the study it was concluded that Karnim plus capsule and Metformin capsule are equally effective in controlling hyperglycemia with slightly more time to achieve significance result in Karnim plus. In case of HbA1c highly significant results were observed in Karnim plus capsule and also highly significance is observed in symptom score of clinical parameters. Cholesterol levels are significantly decreased in Karnim plus group than metformin group. This indicated that Karnim plus is effective remedy in controlling diabetes type II with no any adverse effects and controlling metabolism in a effective way than other OHA.

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Published
2018-07-18
How to Cite
1.
Shrirang C, Sarang D, G KS, Padvi DM, Deodatta B, Shailesh M. A RANDOMISED SINGLE BLIND ACTIVE CONTROLLED, PARALLEL GROUP STUDY COMPARING THE EFFICACY & SAFETY OF THE KARNIM PLUS® CAPSULES IN PATIENTS WITH MILD OR MODERATE DIABETES MELLITUS TYPE. II. IJRAPS [Internet]. 2018Jul.18 [cited 2021Jun.24];1(2):106-12. Available from: https://ijraps.in/index.php/ijraps/article/view/18
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