EVALUATION OF ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF WEDELIA TRILOBATA

  • M.Madhu Babu
  • A Lakshmana Rao
  • V Harshitha
  • V Madhavi
  • V.N.S Lavanya
  • V Vineetha
  • M.Sai Sailaja Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh
Keywords: Wedelia trilobata, Brewer’s yeast, Paracetamol, Digital clinical thermometer.

Abstract

The aim of present study was to investigate antipyretic activity of ethanolic extract of leaves of Wedelia trilobata in yeast induced pyrexia in wistar albino rats. In which pyrexia was induced by an intraperitonial injection of 20% brewer’s yeast (10 ml/kg b.wt.). The body temperature of rats were measured before the injection of yeast and injected ethanolic extract of leaves of Wedelia trilobata (100 mg/kg b.wt.) and (200 mg/kg b.wt.) and followed by treatment with paracetamol (150 mg/kg b.wt.). The body temperature of experimental animals were recorded in the time interval of 0 hr, 1 hr, 2 hr and 3 hr with help of digital clinical thermometer which is placed in rectum in the depth of 2 cm and recorded body temperature values shown that the leaves extract of of Wedelia trilobata possess antipyretic activity.

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Published
2018-06-28
How to Cite
1.
Babu M, Lakshmana Rao A, Harshitha V, Madhavi V, Lavanya V, Vineetha V, Sailaja M. EVALUATION OF ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF WEDELIA TRILOBATA. ijraps [Internet]. 2018Jun.28 [cited 2020Oct.22];2(2):212-26. Available from: https://ijraps.in/index.php/ijraps/article/view/36
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Articles