ESTIMATION OF PAROXETINE HYDROCHLORIDE FROM ITS TABLET FORMULATION BY UV SPECTROPHOTOMETRY

  • A. Lakshmana Rao*, A.B. Hima Bindu, G. Jyothi Stella, Y. Prema Latha and K. Kiranmai Department of Pharmaceutical Analysis, V.V.Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh,
Keywords: Paroxetine, Calibration, Validation, Estimation.

Abstract

A simple, precise and accurate UV Spectrophotometric method was developed for the estimation of Paroxetine hydrochloride. The developed method obeyed Beer-Lambert’s law in the concentration range of 5-30 µg/ml with a correlation coefficient of 0.995. The recovery study was carried out at three different levels and was found to be satisfactory. The percent amount of drug estimated by this method is 100%, found to be in good agreement with label claim of marketed tablet formulation. The validation parameters like linearity, precision, accuracy, robustness and ruggedness were studied and were found to be within limits. The proposed method can be adopted for routine quality control analysis of estimation of Paroxetine hydrochloride in pharmaceutical formulation.

Published
2020-01-08
How to Cite
1.
A. Lakshmana Rao*, A.B. Hima Bindu, G. Jyothi Stella, Y. Prema Latha and K. Kiranmai. ESTIMATION OF PAROXETINE HYDROCHLORIDE FROM ITS TABLET FORMULATION BY UV SPECTROPHOTOMETRY. ijraps [Internet]. 2020Jan.8 [cited 2020Jun.6];3(8):359-63. Available from: https://ijraps.in/index.php/ijraps/article/view/72
Section
Articles