ESTIMATION OF PAROXETINE HYDROCHLORIDE FROM ITS TABLET FORMULATION BY UV SPECTROPHOTOMETRY
A simple, precise and accurate UV Spectrophotometric method was developed for the estimation of Paroxetine hydrochloride. The developed method obeyed Beer-Lambert’s law in the concentration range of 5-30 µg/ml with a correlation coefficient of 0.995. The recovery study was carried out at three different levels and was found to be satisfactory. The percent amount of drug estimated by this method is 100%, found to be in good agreement with label claim of marketed tablet formulation. The validation parameters like linearity, precision, accuracy, robustness and ruggedness were studied and were found to be within limits. The proposed method can be adopted for routine quality control analysis of estimation of Paroxetine hydrochloride in pharmaceutical formulation.